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TIM STAKENBORG, IMEC
GROUP LEADER BIODEVICES, LIFE SCIENCE AND IMAGING


Dr. Tim Stakenborg (Master in bioengineering; PhD in molecular biology) graduated in 1998 at the University of Leuven as a master in engineering in chemistry and biochemistry. His first research project in the field of vaccinology has resulted in a patent and was honoured with a laureate prize. For his work in the field of molecular biology, he was granted a PhD in 2005 at the University of Ghent after which he joined IMEC as a postdoctoral fellow. During his role of team-leader, he was involved in several research projects focusing on merging biology with technology. In his current role of group leader of biodevices, he is mainly involved in the transfer and integration of key technical components in fully functional devices for life science applications.

 

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Presentation abstract

NUCLEIC ACID AMPLIFICATION USING SILICON CHIPS

Liquid biospies are non- or minimal invasive diagnostic tests using easy accessible body fluids such as blood or urine hoping to replace the need for more invasive procedures. Cell-free DNA (cfDNA), circulating cells or nucleic acids encapsulated in vesicles (e.g. exosomes) are all explored as a promising supply for novel molecular markers. While clinical trials are ongoing to better understand the use of such markers in a medical setting, there is a similar need for novel technologies to facilitate detection. We describe the development and use of silicon PCR chips for a fast and miniaturized nucleic acid amplification and detection. By further integration of a droplet generator, similar chip structures were also used to demonstrate digital PCR. This amplification method, based on reaction partitioning and end-point detection, is often selected for detecting rare targets or for highly accurate quantification. These chip technologies combined with efforts in biomarker discovery may facilitate the continuous progress towards improved, less-invasive diagnostics.

 

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