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Alexandra Dusa    
   

 

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ALEXANDRA DUSA, IMEC
SENIOR R&D BIO-APPLICATIONS SCIENTIST, LIFE SCIENCE AND IMAGING


Alexandra Dusa received a BSc degree in Molecular and Cell Biology from the University of California Berkeley and a MSc degree in Biochemistry from the University of California Santa Cruz, working on structure-function relationships of proteins involved in Parkinson’s Disease. She then jumped across the pond to pursue a PhD in Biomedical and Pharmaceutical Sciences at the Universite Catholique de Louvain and the Ludwig Institute for Cancer Research Brussels, under a Belgian American Educational Foundation fellowship. Her PhD work investigated a point mutation in a kinase protein involved in a group of blood cancers and she proposed the first molecular mechanism of activation, which was later confirmed by a crystal structure of the protein and led to new efforts in the development of specific inhibitors. She joined imec in 2011 as a bio-application specialist, and has been instrumental in imec projects by suggesting and performing specific validation experiments to compare novel technologies to conventional existing offerings, as well as lead technological development efforts from the application point of view.

 

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Presentation abstract

ON-CHIP CLINICAL CELL SORTING FOR LIQUID BIOPSIES

The ability to detect circulating tumor cells (CTCs) in the peripheral blood of cancer patients, as well as physically sorting the cells to enable accurate downstream analysis, holds great promise toward next-generation personalized treatment. Given their very low concentration in whole blood, as well as their morphological heterogeneity, identifying and sorting CTCs remains technically challenging. New microfluidic chip-based technologies are presently being developed to address these challenges. In this talk we give a brief overview into imec’s efforts to develop novel technologies facilitating accurate detection and sorting of CTCs, bringing personalized medicine one step closer to the patient’s bedside.

 

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